Publications

Selected Peer Reviewed Publications

Chiral glycine cation equivalents: N-acyliminium species derived from diketopiperazines. , Bull, S. D.; Davies, S. G.; Garner, A. C.; O’Shea, M. D.; Savory, E. D.; Snow, E. J.  J. Chem. Soc., Perkin Trans. 1. 2002, (22), 2442.  (254kb)

Conjugate additions of organocuprates to a 3-methylene-6-isopropyldiketopiperazine acceptor for the asymmetric synthesis of homochiral β-amino acids. ,  Bull, S. D.; Davies, S. G.; Garner, A. C.; O’Shea, M. D. J. Chem. Soc., Perkin Trans. 1. 2001, (24), 3281.  (139kb)

Stereoselective conjugate addition of organocuprates to a dehydroalanine derived diketopiperazine. , Bull, S. D.; Davies, S. G.; O’Shea, M. D. J. Chem. Soc., Perkin Trans. 1. 1998, (22), 3657.  (141kb)

Synthetic approaches to the Angucyclinone antibiotics: A concise entry to the ring system of PD 116740 and TAN 1085. , Larsen, D. S.; O’Shea, M. D. J. Org. Chem. 1996, (61), 5681.   (200kb) and, for supporting information,  (329kb)

Total syntheses of the Angucyclinone antibiotics (+) Emycin A and (+) Ochromycinone. , Brooker, S.; Larsen, D. S.; O’Shea, M. D.Chem Commun. 1996, 203.  (276kb)

Synthetic approaches to the Angucyclinone antibiotics: The total synthesis of (±) Rubiginone B1 and B2, (±) Emycin A, and related analogues. , Larsen, D. S.; O’Shea, M. D. J. Chem. Soc., Perkin Trans. 1. 1995, 1019.  (1540kb)

A stereoselective approach to the Angucyclinone antibiotics: A total synthesis of (±) Rubiginone B1. , Larsen, D. S.; O’Shea, M. D.Tetrahedron Lett. 1993, (34), 3679.

A stereoselective approach to the Angucyclinone antibiotics: A total synthesis of the C-1 epimer of (±) Rubiginone B1. , Larsen, D. S.; O’Shea, M. D. Tetrahedron Lett. 1993, (34), 1373.

Acknowledgements

Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. Vaidya, J. S. et al, 2010, The Lancet

Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial. Vaidya, J. S. et al, 2013, The Lancet 

Effect of Delayed Targeted Intraoperative Radiotherapy vs Whole-Breast Radiotherapy on Local Recurrence and Survival. Long-term Results From the TARGIT-A Randomized Clinical Trial in Early Breast Cancer. Vaidya, J. S. et al, 2020, JAMA Oncology

Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomise clinical trial. Vaidya, J. S. et al, 2020 BMJ

International Conference Presentations

A Software System for Automated HTA in Heterogeneous Empower, ChemStation, and MassLynx Controlled Analytical Systems Using a Single Common User Interface., 2008, see Consult-igma or Tessella for the Chromatographic Society abstract for this lecture.

Development and Implementation of an Informatics Solution to Enable Analytical Quality By Design (AQbD) LC Methods Development , see PittCon 2013 abstract.

Theses

M.Sc. Trithiocarbon Systems In Organic Synthesis

Ph.D. Synthetic Approaches To The Angucyclinone Antibiotics